| Ronde van 16 | ||||||||
|---|---|---|---|---|---|---|---|---|
| 03/11/2021 | 17:55 | AFC Ajax | AFC Ajax | | BSC Young Boys | BSC Young Boys | | |
| 03/11/2021 | 17:55 | Dynamo Kiev | Dynamo Kiev | | Villarreal CF | Villarreal CF | | |
| 03/11/2021 | 17:55 | Manchester United | Manchester United | | AC Milaan | AC Milaan | | |
| 03/11/2021 | 17:55 | Slavia Praag | Slavia Praag | | Rangers FC | Rangers FC | | |
| 03/11/2021 | 20:00 | AS Roma | AS Roma | | Shakhtar Donetsk | Shakhtar Donetsk | | |
| 03/11/2021 | 20:00 | Olympiakos Piraäus | Olympiakos Piraäus | | Arsenal FC | Arsenal FC | | |
| 03/11/2021 | 20:00 | Tottenham Hotspur | Tottenham Hotspur | | Dinamo Zagreb | Dinamo Zagreb | | |
| 03/11/2021 | 20:00 | Granada CF | Granada CF | | Molde FK | Molde FK | | |
| 18/03/2021 | 17:55 | Shakhtar Donetsk | Shakhtar Donetsk | | AS Roma | AS Roma | | |
| 18/03/2021 | 17:55 | Arsenal FC | Arsenal FC | | Olympiakos Piraäus | Olympiakos Piraäus | | |
| 18/03/2021 | 17:55 | Dinamo Zagreb | Dinamo Zagreb | | Tottenham Hotspur | Tottenham Hotspur | | |
| 18/03/2021 | 17:55 | Molde FK | Molde FK | | Granada CF | Granada CF | | |
| 18/03/2021 | 20:00 | BSC Young Boys | BSC Young Boys | | AFC Ajax | AFC Ajax | | |
| 18/03/2021 | 20:00 | Villarreal CF | Villarreal CF | | Dynamo Kiev | Dynamo Kiev | | |
| 18/03/2021 | 20:00 | AC Milaan | AC Milaan | | Manchester United | Manchester United | | |
| 18/03/2021 | 20:00 | Rangers FC | Rangers FC | | Slavia Praag | Slavia Praag | | |
| Kwartfinales | ||||||||
| 04/08/2021 | N.N. | N.N. | | N.N. | N.N. | | ||
| 15/04/2021 | N.N. | N.N. | | N.N. | N.N. | |
| | | |
