| 27. Ronde | ||||||||
|---|---|---|---|---|---|---|---|---|
| 03/06/2021 | 12.30 uur | Burnley FC | Burnley FC | | Arsenal FC | Arsenal FC | | |
| 03/06/2021 | 15.00 uur | Sheffield United | Sheffield United | | Southampton FC | Southampton FC | | |
| 03/06/2021 | 17:30 | Aston Villa | Aston Villa | | Wolverhampton Wanderers | Wolverhampton Wanderers | | |
| 03/06/2021 | 20:00 | Brighton & Hove Albion | Brighton & Hove Albion | | Leicester stad | Leicester stad | | |
| 03/07/2021 | 12.00 uur | West Bromwich Albion | West Bromwich Albion | | Newcastle United | Newcastle United | | |
| 03/07/2021 | 14:00 | Liverpool FC | Liverpool FC | | Fulham FC | Fulham FC | | |
| 03/07/2021 | 16.30 uur | Manchester City | Manchester City | | Manchester United | Manchester United | | |
| 03/07/2021 | 19:15 | Tottenham Hotspur | Tottenham Hotspur | | Crystal Palace | Crystal Palace | | |
| 03/08/2021 | 18:00 | Chelsea FC | Chelsea FC | | Everton FC | Everton FC | | |
| 03/08/2021 | 20:00 | West Ham United | West Ham United | | Leeds United | Leeds United | | |
| 28. Ronde | ||||||||
| 03/12/2021 | 20:00 | Newcastle United | Newcastle United | | Aston Villa | Aston Villa | | |
| 13/03/2021 | 12.30 uur | Leeds United | Leeds United | | Chelsea FC | Chelsea FC | | |
| 13/03/2021 | 15.00 uur | Crystal Palace | Crystal Palace | | West Bromwich Albion | West Bromwich Albion | | |
| 13/03/2021 | 17:30 | Everton FC | Everton FC | | Burnley FC | Burnley FC | | |
| 13/03/2021 | 20:00 | Fulham FC | Fulham FC | | Manchester City | Manchester City | | |
| 14/03/2021 | 12.00 uur | Southampton FC | Southampton FC | | Brighton & Hove Albion | Brighton & Hove Albion | | |
| 14/03/2021 | 14:00 | Leicester stad | Leicester stad | | Sheffield United | Sheffield United | | |
| 14/03/2021 | 16.30 uur | Arsenal FC | Arsenal FC | | Tottenham Hotspur | Tottenham Hotspur | | |
| 14/03/2021 | 19:15 | Manchester United | Manchester United | | West Ham United | West Ham United | | |
| 15/03/2021 | 20:00 | Wolverhampton Wanderers | Wolverhampton Wanderers | | Liverpool FC | Liverpool FC | | |
| 29. Ronde | ||||||||
| 03/03/2021 | 18:00 | Burnley FC | Burnley FC | | Leicester stad | Leicester stad | 1: 1 (1: 1) | |
| 03/03/2021 | 18:00 | Sheffield United | Sheffield United | | Aston Villa | Aston Villa | 1: 0 (1: 0) | |
| 03/03/2021 | 20:15 | Crystal Palace | Crystal Palace | | Manchester United | Manchester United | 0: 0 (0: 0) | |
| 03/04/2021 | 18:00 | West Bromwich Albion | West Bromwich Albion | | Everton FC | Everton FC | 0: 1 (0: 0) | |
| 03/04/2021 | 20:15 | Liverpool FC | Liverpool FC | | Chelsea FC | Chelsea FC | 0: 1 (0: 1) | |
| 33. Rond | ||||||||
| 03/04/2021 | 18:00 | Fulham FC | Fulham FC | | Tottenham Hotspur | Tottenham Hotspur | 0: 1 (0: 1) | |
| 03/10/2021 | 18:00 | Manchester City | Manchester City | | Southampton FC | Southampton FC | | |
| | | |
Overdrachten
| 02/21 | Marcos Rojo | Marcos Rojo | Manchester United | Manchester United | | Boca Juniors | Boca Juniors |
| 02/21 | Josh Maja | Josh Maja | Girondins Bordeaux | Girondins Bordeaux | | Fulham FC | Fulham FC |
| 02/21 | Joshua King | Joshua King | AFC Bournemouth | AFC Bournemouth | | Everton FC | Everton FC |
| 02/21 | Takumi Minamino | Takumi Minamino | Liverpool FC | Liverpool FC | | Southampton FC | Southampton FC |
| 02/21 | Shkodran Mustafi | Shkodran Mustafi | Arsenal FC | Arsenal FC | | FC Schalke 04 | FC Schalke 04 |
| 02/21 | Paulo Gazzaniga | Paulo Gazzaniga | Tottenham Hotspur | Tottenham Hotspur | | Elche CF | Elche CF |
| 02/21 | Ozan Kabak | Ozan Kabak | FC Schalke 04 | FC Schalke 04 | | Liverpool FC | Liverpool FC |
| 02/21 | Ben Davies | Ben Davies | Preston North End | Preston North End | | Liverpool FC | Liverpool FC |
| 02/21 | Meritan Shabani | Meritan Shabani | Wolverhampton Wanderers | Wolverhampton Wanderers | | VVV-Venlo | VVV-Venlo |
| 02/21 | Oké Yokuşlu | Oké Yokuşlu | Keltische vigo | Keltische vigo | | West Bromwich Albion | West Bromwich Albion |
