| 18. Ronde | ||||||||
|---|---|---|---|---|---|---|---|---|
| 03/10/2021 | 18:00 | Atletico Madrid | Atletico Madrid | | Athletic Bilbao | Athletic Bilbao | | |
| 26. Ronde | ||||||||
| 03/05/2021 | 20:00 | Valencia CF | Valencia CF | | Villarreal CF | Villarreal CF | | |
| 03/06/2021 | 13.00 uur | Echt Valladolid | Echt Valladolid | | Getafe CF | Getafe CF | | |
| 03/06/2021 | 15:15 | Elche CF | Elche CF | | Sevilla FC | Sevilla FC | | |
| 03/06/2021 | 17:30 | Cádiz CF | Cádiz CF | | SD Eibar | SD Eibar | | |
| 03/06/2021 | 20:00 | CA Osasuna | CA Osasuna | | FC Barcelona | FC Barcelona | | |
| 03/07/2021 | 13.00 uur | SD Huesca | SD Huesca | | Keltische vigo | Keltische vigo | | |
| 03/07/2021 | 15:15 | Atletico Madrid | Atletico Madrid | | Real Madrid | Real Madrid | | |
| 03/07/2021 | 17:30 | Echte samenleving | Echte samenleving | | Til UD op | Til UD op | | |
| 03/07/2021 | 20:00 | Athletic Bilbao | Athletic Bilbao | | Granada CF | Granada CF | | |
| 03/08/2021 | 20:00 | Echte Betis | Echte Betis | | CD Alaves | CD Alaves | | |
| 27. Ronde | ||||||||
| 03/12/2021 | 20:00 | Til UD op | Til UD op | | Valencia CF | Valencia CF | | |
| 13/03/2021 | 13.00 uur | CD Alaves | CD Alaves | | Cádiz CF | Cádiz CF | | |
| 13/03/2021 | 15:15 | Real Madrid | Real Madrid | | Elche CF | Elche CF | | |
| 13/03/2021 | 17:30 | CA Osasuna | CA Osasuna | | Echt Valladolid | Echt Valladolid | | |
| 13/03/2021 | 20:00 | Getafe CF | Getafe CF | | Atletico Madrid | Atletico Madrid | | |
| 14/03/2021 | 13.00 uur | Keltische vigo | Keltische vigo | | Athletic Bilbao | Athletic Bilbao | | |
| 14/03/2021 | 15:15 | Granada CF | Granada CF | | Echte samenleving | Echte samenleving | | |
| 14/03/2021 | 17:30 | SD Eibar | SD Eibar | | Villarreal CF | Villarreal CF | | |
| 14/03/2021 | 20:00 | Sevilla FC | Sevilla FC | | Echte Betis | Echte Betis | | |
| 15/03/2021 | 20:00 | FC Barcelona | FC Barcelona | | SD Huesca | SD Huesca | |
| | | |
Overdrachten
| 02/21 | Santiago Cáseres | Santiago Cáseres | Villarreal CF | Villarreal CF | | Velez Sarsfield | Velez Sarsfield |
| 02/21 | Helibelton Palacios | Helibelton Palacios | | Elche CF | Elche CF | ||
| 02/21 | Adrian Marin | Adrian Marin | CD Alaves | CD Alaves | | Granada CF | Granada CF |
| 02/21 | Paulo Gazzaniga | Paulo Gazzaniga | Tottenham Hotspur | Tottenham Hotspur | | Elche CF | Elche CF |
| 02/21 | Denis Vavro | Denis Vavro | Lazio Rome | Lazio Rome | | SD Huesca | SD Huesca |
| 02/21 | Oussama Idrissi | Oussama Idrissi | Sevilla FC | Sevilla FC | | AFC Ajax | AFC Ajax |
| 02/21 | Ramalho | Ramalho | Girona FC | Girona FC | | CA Osasuna | CA Osasuna |
| 02/21 | Christian Oliva | Christian Oliva | Voetbal van Cagliari | Voetbal van Cagliari | | Valencia CF | Valencia CF |
| 02/21 | Oké Yokuşlu | Oké Yokuşlu | Keltische vigo | Keltische vigo | | West Bromwich Albion | West Bromwich Albion |
| 02/21 | Dominic Quina | Dominic Quina | Watford FC | Watford FC | | Granada CF | Granada CF |
